Chromate pigment is formed with which fixative?

Study for the CAMLPR Histology Practice Test. Study with flashcards and multiple choice questions, each question has hints and explanations. Get ready for your exam!

Chromate pigment is an artifact that forms when chromium-containing fixatives are used. Potassium dichromate fixative introduces chromate ions into tissues, and during processing chromium can be reduced and precipitate as an insoluble chromium oxide/hydroxide pigment. This yellow-brown chromate pigment remains in the tissue and is a hallmark of chromium-based fixation, which is why this fixative is the correct choice.

Other fixatives don’t contain chromium, so they don’t produce chromate pigment. Unbuffered formalin can cause other formalin-related pigments, osmium tetroxide fixative leads to osmium deposits, and picric acid fixative can leave picrate-related deposits.