When embedding multiple pieces of tissue such as curettage or prostate specimens that are in fragments, which orientation is recommended?

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When embedding fragmented tissues, the goal is to preserve and visualize the edges of each piece so margins and tissue architecture can be accurately assessed. Placing the fragments with as much surface edge exposed as possible, all oriented in the same direction on the same embedding plane and laid side by side rather than on top of one another, provides a flat, uniform surface for sectioning. This arrangement minimizes overlap and compression, making edge visibility and margin assessment consistent across sections. Random placement, stacking with edges hidden, or arranging pieces to maximize other features tends to obscure edges, distort margins, and hinder interpretation.